Angiostatin Inhibits Bone Metastasis Formation in Nude Mice through a Direct Anti-osteoclastic Activity
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چکیده
منابع مشابه
Reduction of Bone Resorption Osteolytic Bone Metastasis in Nude Mice through the Angiogenesis Inhibitor TNP-470 Inhibits Human Breast Cancer
Angiogenesis inhibitor TNP-470, 6-O-(A'-chloroacetyl-carbamoyl)-fumagillol, semisynthetic analogue of fumagillin, has strong inhibitory activ ities against in vivo tumor growth and metastasis in a wide variety of tumors. However, it is still unknown whether this agent inhibits bone metastasis. We examined the effects of TNP-470 in a bone metastasis model in nude mice in which intracardiac injec...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m309024200